Key proteins such as mitogen-activated protein kinase 3 (Mapk3), protein BUD31 homolog (Bud31), heterogeneous nuclear ribonucleoprotein K (Hnrnpk), elongation factor 1-alpha (Eef1a1, Eef1a2), small ribosomal subunit proteins (Rps10, 11, 17, 20), and large ribosomal subunit proteins (Rpl23, 24, 38) were found to be highly associated with SUDEP and identified as potential plasma biomarkers. Here, MAP2K3 is linked to Sudden unexpected death in epilepsy.