Neurotensin receptor 1 (NTSR1), a G protein-coupled receptor, is overexpressed in LUAD and linked to poor prognosis, but its therapeutic potential is underexplored.<h4>Methods</h4>This study combined multi-database bioinformatics to systematically evaluate the expression, prognostic relevance, genetic alterations, and immune-microenvironment association of NTSR1 across cancer types. Here, NTSR1 is linked to cancer.