Key findings were validated by RT-qPCR in cellular models and further supported using LUAD patient cohorts from the UALCAN platform.<h4>Results</h4>Bioinformatics analysis confirmed significant upregulation of NTSR1 in LUAD, and its high expression was closely associated with advanced tumor stage, remodeled immune microenvironment, and poor overall patient survival. This evidence concerns the gene NTSR1 and neoplasm.