This study aimed to clarify whether the identification of circulating CAFs (cir-CAFs) by THBS4 is detectable in the blood of gastric cancer (GC) patients, and whether cir-CAFs are useful for the screening test of GC.<h4>Materials and methods</h4>CAFs and normal fibroblasts (NFs) were respectively established from 17 GC specimens. This evidence concerns the gene THBS4 and gastric cancer.