In the low-IFTA subgroup, there were significant differences in systolic blood pressure, proteinuria, and total cholesterol levels across the levels of tubular TLR4 expression.<h4>Conclusion</h4>These findings indicate possible involvement of TLR4 expression in histological injury and poor renal prognosis in DN, especially before the development of extensive fibrosis. Here, TLR4 is linked to liver dysplastic nodule.