SIRT1 and diabetic kidney disease: <h4>Objective</h4>This study aims to evaluate the renoprotective effects of QGDD in a DKD model exhibiting metabolic memory features and to explore its potential mechanism involving the regulation of ferroptosis <i>via</i> the SIRT1/Nrf2 signaling pathway.<h4>Methods</h4>A DKD rat model was induced using streptozotocin (STZ).