STAT1 and acute respiratory distress syndrome: In summary, this study reveals that hv<i>Kp</i> infection triggers STAT1-dependent PANoptosis in AMs, leading to immune cell death, organ failure, and high mortality, providing new insights into the pathogenesis of severe <i>Kp</i> infections.IMPORTANCE<i>Klebsiella pneumoniae</i>, particularly hypervirulent strains (hv<i>Kp</i>), poses a critical public health threat due to its capacity to cause severe, rapidly progressing infections such as pneumonia and sepsis, often leading to acute lung injury (ALI) and high mortality.