In summary, this study reveals that hv<i>Kp</i> infection triggers STAT1-dependent PANoptosis in AMs, leading to immune cell death, organ failure, and high mortality, providing new insights into the pathogenesis of severe <i>Kp</i> infections.IMPORTANCE<i>Klebsiella pneumoniae</i>, particularly hypervirulent strains (hv<i>Kp</i>), poses a critical public health threat due to its capacity to cause severe, rapidly progressing infections such as pneumonia and sepsis, often leading to acute lung injury (ALI) and high mortality. The gene discussed is STAT1; the disease is Sepsis.