In co-culture, rVSVΔG-ZEBOV-GP-infected monocytes serve as a source to synoviocyte infection, resulting in distinct kinetics modulation in innate biomarkers (transcription and secretion) and upregulation of specific genes, such as <i>NEDD8</i> and <i>SIGLEC-1</i>, which have been associated with inflammatory arthritis in animal models. Here, SIGLEC1 is linked to infection.