Functional studies of the new candidate genes for CHH were not undertaken.<h4>Wider implications of the findings</h4>This study highlights the importance of comprehensive clinical evaluation and broadened genetic testing in patients with Gn deficiency.<h4>Study funding/competing interests</h4>This work was supported by the Swiss National Foundation (NP) (Grant No. 310030B_201275 to N.P.)and the Natural Science Foundation of Beijing (Grant No. 7244338 to Y.W.). This evidence concerns the gene RMRP and mucopolysaccharidosis type 3D.