Compared with metformin, GLP-1 RAs were associated with significant reductions in serum testosterone (standardized mean difference (SMD) = -0.327, p = 0.036), dehydroepiandrosterone sulfate (DHEA-S) (SMD = -0.528, p = 0.048), androstenedione (SMD = -0.523, p = 0.002), and insulin resistance as assessed by the homeostasis model assessment of insulin resistance (HOMA-IR) (SMD = 1.217, p < 0.001). The gene discussed is GLP1R; the disease is Insulin resistance.