This study shows that CD64 has superior diagnostic performance compared to CRP and PCT in bacterial infections.<h4>Methods</h4>This retrospective study analyzed 242 febrile patients admitted to the Jiangsu Province (Suqian) Hospital (January 2023-December 2024), categorized into non-specific fever (n = 186) and scrub typhus (n = 56). The gene discussed is CRP; the disease is scrub typhus.