ELANE and type 1 diabetes mellitus: This study aimed to evaluate the feasibility of imaging innate immune cells in vivo using positron emission tomography (PET).<h4>Methods</h4>We used PET tracers targeting M1 macrophages ([<sup>68</sup>Ga]-DOTATATE) and neutrophil elastase ([<sup>11</sup>C]-NES) to assess pancreatic immune cell infiltration in individuals with new-onset T1D (n = 4), long-standing T1D (n = 6), and healthy controls (n = 6).<h4>Results</h4>Both tracers enabled visualisation and quantification of pancreatic uptake.