Moreover, HDM treatment triggered a pronounced pro-inflammatory response, as evidenced by the elevated mRNA expression of cytokines IL-25, IL-33, TSLP, IL-6, and IL-8.<h4>Conclusion</h4>Our findings reveal an association between disulfidptosis-related gene signatures and AD pathogenesis, suggesting that this pathway may contribute to the inflammatory response observed in lesional skin. The gene discussed is IL25; the disease is Alzheimer disease.