In this study, we aimed to evaluate the therapeutic potential of LY294002 (a PI3K/Akt inhibitor) and lithium chloride (LiCl) (a GSK3β inhibitor) in a neonatal mouse model of ExPEC meningitis.<h4>Methods</h4>Neonatal mice were infected with clinical ExPEC isolates to induce meningitis. The gene discussed is AKT1; the disease is infectious meningitis.