TNF and common variable immunodeficiency: The heterozygous NFKB1 variant similarly reduced NFKB1 protein in CVID patient- and healthy donor-derived iMONOs, but elevated LPS-induced IL-1β release and expression of inflammatory genes, including IL1B, IL6, TNF, and neutrophil chemoattractants, only in CVID patient iMONOs.