After validating using the GEO datasets and human sub-epicardial adipose samples, <i>STAT3, SERPINE1, CDKN2A, DLG4, PTGS2, MDM2, LRP1, IRS2, PRKCD, CCND2</i>, and <i>CISH</i> were found to be significantly expressed in the group with severe CAD. The gene discussed is CISH; the disease is coronary artery disorder.