The joint ROC of all 5 genes expression was 1.<h4>Conclusion</h4>These screened SASP hub genes, including <i>STAT3, LRP1, PRKCD, CCND2</i>, and <i>CISH,</i> may affect cell senescence after hypoxia, thus inducing CAD progression. The gene discussed is CISH; the disease is coronary artery disorder.