The area under the curve (AUC) was significantly higher in the case of the combined diagnosis of CHD with NLR, MLR, and CRP/ALB (AUC reached 0.931, with a sensitivity of 86.33% and a specificity of 83.86%), which was significantly better than that of single-indicator diagnosis (all <i>P</i> < 0.001).<h4>Conclusion</h4>The levels of NLR, MLR, and CRP/ALB in CHD patients were all significantly and positively correlated with the degree of coronary artery disease; moreover, the levels of NLR, MLR, and CRP/ALB have high diagnostic and predictive value for CHD patients. This evidence concerns the gene ALB and coronary artery disorder.