The immunophenotypic effects of LAG3 blockade were evaluated in septic mice.<h4>Results</h4>Single-cell analysis identified a GZMB<sup>+</sup>CD8<sup>+</sup> T-cell population with an exhaustion-like transcriptional program in sepsis, characterized by increased expression of inhibitory receptors including LAG3 and elevated ZNF683. This evidence concerns the gene CD8A and Sepsis.