RNA FISH further showed reduced ZNF683 signals in the lungs and liver of septic mice following LAG3 blockade.<h4>Conclusion</h4>ZNF683 is associated with an exhaustion-like GZMB<sup>+</sup>CD8<sup>+</sup> T cell state in sepsis and may contribute to persistent T-cell dysfunction. This evidence concerns the gene CD8A and Sepsis.