NFKB1 and Menkes disease: Key findings were validated in an independent cohort through measurement of serum cytokines, <i>in vitro</i> macrophage stimulation assays, and immunofluorescence staining.<h4>Results</h4>Bioinformatic analysis revealed a latent hyperinflammatory potential in MD PBMCs, which was unmasked upon fungal challenge, showing significant enrichment in neutrophil chemotaxis and NF-κB pathways.