CXCL8 and Menkes disease: Serum levels of CXCL8, IL-6, and IL-17A were also significantly elevated in MD patients during attacks.<h4>Conclusion</h4>Our findings support a novel "hypoimmune-hyperinflammatory switch" model in MD, wherein macrophages play an important role in initiating and amplifying inflammatory responses to environmental triggers via CXCL8 production and cellular crosstalk.