CADM2 and esophageal squamous cell carcinoma: Clinically, DNMT3B overexpression in lymph node-positive tumors correlated with metastatic progression.<h4>Discussion</h4><i>ADAMTS9-AS2</i> functions as an epigenetic brake by sequestering DNMT3B, thereby blocking <i>CADM2</i> epigenetic silencing and metastasis in ESCC.