Through qRT-PCR validation, the CAMK1D gene was markedly upregulated in lung adenocarcinoma cell lines, whereas BCAS3, DNAH1, PDE10A, and C18orf63 genes exhibit ed substantially reduced expression.<h4>Conclusion</h4>Our study identified specific gut microbial taxa as risk factors for lung adenocarcinoma and proposes <i>CAMK1D</i> as a microbiota-related candidate biomarker and potential therapeutic target that may inform personalized treatment and drug development strategies in the future. Here, PDE10A is linked to lung adenocarcinoma.