Subsequent multivariable logistic regression analysis revealed that the number of infarcts (OR = 2.17, 95% CI: 1.65-2.86, <i>p</i> < 0.001), C-reactive protein level (OR = 1.02, 95% CI: 1.01-1.03, <i>p</i> = 0.002), and left-sided frontal lobe infarction (OR = 4.56, 95% CI: 1.97-10.55, <i>p</i> < 0.001), among others, were independent risk factors for cognitive impairment after acute ischemic stroke (AIS). This evidence concerns the gene CRP and androgen insensitivity syndrome.