DLG4 and brain ischemia: <i>In vivo</i> experiments confirmed the efficacy of NST in ameliorating memory deficits, mitigating synaptic structural damage, and upregulating key synaptic protein expression (SYN and PSD95) in mice.<h4>Conclusion</h4>NST may protect against cerebral ischemia/reperfusion injury by modulating lncRNA and mRNA expressions to enhance synaptic plasticity, thereby preserving neuronal structure and function.