HIF1A and diabetes mellitus: A significant correlation was found between SNR and HIF-1α (r = - 0.553; <i>p</i>  = 0.004) and VEGF-A (r = - 0.564; <i>p</i>  = 0.003), indicating that lower levels of these factors were associated with higher SNR.<h4>Conclusion</h4>Curcuminoids can prevent and treat outer hair cell damage in the organ of Corti due to DM, as shown by improvements in plasma HIF-1α, VEGF-A levels, and SNR values.