Although curcuminoids show therapeutic promise, no validated options are available to repair organ of Corti damage caused by DM.<h4>Objective</h4>The present study aims to evaluate the effects of curcuminoid administration on the signal-to-noise ratio (SNR) and plasma levels of HIF-1α and VEGF-A in a DM model using <i>Rattus norvegicus</i> .<h4>Methods</h4>An in vivo experimental design was employed with a double-blind control set up. The gene discussed is VEGFA; the disease is diabetes mellitus.