A bar graph was generated to illustrate the predictive weights of these genes concerning sciatica risk, further complemented by immune cell composition analysis via CIBERSORTx, which underscored significant correlations between these genes and the abundance of various immune cell types in affected individuals.<h4>Conclusion</h4>Our findings substantiate the critical roles of <i>KLRK1</i>, <i>LRRK2</i>, <i>NLRP3</i>, and <i>PLG</i> in the neuroinflammation-associated pathogenesis of sciatica, providing pivotal insights into the biological underpinnings of this condition. Here, NLRP3 is linked to Sciatica.