<h4>Introduction</h4>To preliminarily describe the dynamic changes and clinical characteristics of serum C-reactive protein (CRP) in giant omphalocele (GO) neonates with delayed repair during the early postnatal period.<h4>Methods</h4>A retrospective study included 15 neonates with GO who underwent delayed repair at our hospital. This evidence concerns the gene CRP and geroderma osteodysplastica.