Moreover, taurine suppressed lipid accumulation by inhibiting CB1 signaling, a mechanism supported by downregulation of lipogenic genes (including <i>Srebf1</i>, <i>Acaca</i>, <i>Cd36</i>, and <i>Pparg</i>) and upregulation of lipolytic genes (including <i>Pnpla2</i>, <i>Lipe</i>, and <i>Ppargc1a</i>).<h4>Conclusion</h4>Collectively, our findings demonstrate that taurine exerts its anti-obesity effects partially via modulation of eCB-CB1 signaling, coordinately inhibiting lipogenesis and promoting lipolysis, thereby highlighting its therapeutic potential for obesity management. Here, PNPLA2 is linked to obesity disorder.