<b>The aim of this study</b> was to study the role of transmission electron microscopy (TEM) in assessment of the phenotype of astrocytes obtained with the directed differentiation technique from induced pluripotent stem cells (iPSCs) from a healthy donor and from a patient with a hereditary form of Parkinson's disease (PD).<h4>Materials and methods</h4>Monolayer astrocyte cultures differentiated from iPSCs from a healthy donor and a PD patient having the G2019S mutation in the <i>LRRK2</i> gene were used in the study. This evidence concerns the gene LRRK2 and Parkinson disease.