IL-6 was notably negatively correlated with APTT (p<i>=</i>0.002, <i>r=</i>-0.432); it was extremely significantly negatively correlated with PT (p<i>=</i>0.000, <i>r=</i>-0.536); it was notably positively correlated with plasma FIB content (p<i>=</i>0.001, <i>r=</i>0.445).<h4>Conclusions</h4>The coagulation function and peripheral blood inflammatory markers in patients with T2DM complicated by IS were significantly different compared to those in patients with T2DM alone and healthy volunteers. Here, IL6 is linked to type 2 diabetes mellitus.