Forced expression of ZEB1 did a reversal of circ-RERE suppression-induced effects.<h4>Conclusion</h4>In a word, circ-RERE promotes autophagy and immune escape in AML by regulating PD-L1 expression through the miR-128-3p/ZEB1 axis, which may provide a new target for AML therapy. Here, ZEB1 is linked to acute myeloid leukemia.