RT-PCR for JAK1 and JAK3 was done in the skin specimens obtained from patients and controls.<h4>Results</h4>Both JAK1 and JAK3 fold changes showed stepwise upregulation in lesional MF skin than normal control skin, with statistically significant increase in MF patients than healthy controls (p < 0.001 and < 0.001 respectively). The gene discussed is JAK3; the disease is mycosis fungoides.