In LPS-stimulated Jurkat cells, hsa_circ_0000313 knockdown suppressed the p38 MAPK pathway via the miR-1224-3p/MKNK2 axis, which reduced inflammatory cytokine secretion and cell proliferation as well as promoted apoptosis.<h4>Conclusion</h4>Hsa_circ_0000313 is involved in MG progression by regulating the miR-1224-3p/MKNK2 axis and can act on the p38MAPK pathway to participate in the progression of MG concomitant inflammatory infections, which may provide a promising therapeutic target in MG. The gene discussed is MKNK2; the disease is myasthenia gravis.