In contrast, overexpression of GPR110 selectively in glutamatergic neurons reduced anxiety- and compulsive-like behaviors with enhanced receptor-mediated signaling and proteins linked to neuronal morphogenesis and synaptic communication.<h4>Discussion</h4>Together, these findings demonstrate that GPR110 regulates anxiety-related and cognitive behaviors in adult mice and modulates synaptic and signaling pathways that support neuronal structure and communication. Here, ADGRF1 is linked to Anxiety.