ALAN was positively associated with T2DM and FPG, and negatively associated with insulin, HOMA-IR, as well as HOMA-β, and the effect sizes of per-quartile increase in ALAN were 1.24(1.19, 1.28), 0.14(0.13, 0.16), -1.19(-1.24, -1.14), -0.22(-0.25, -0.20), and -27.30(-29.11, -25.48), respectively. The gene discussed is INS; the disease is type 2 diabetes mellitus.