<h4>Objective</h4>To investigate the genetic and molecular role of CAPZA1 in asthenozoospermia and its impact on sperm motility and flagellar integrity.<h4>Methods</h4>Whole-exome sequencing (WES) was first performed in an infertile family with asthenozoospermia to identify candidate variants. This evidence concerns the gene CAPZA1 and Infertility.