This meta-analysis systematically evaluates the APOE-HS association to clarify its role in stroke pathophysiology.<h4>Methods</h4>A comprehensive literature search was conducted across multiple databases up to January 31, 2025, using the keywords: ("Apolipoprotein E" OR "APOE" OR "APOE genotype") AND ("Single Nucleotide Polymorphisms" OR "SNP") AND ("Hemorrhagic stroke" OR "HS" OR "Intracerebral Hemorrhage" OR "ICH"). The gene discussed is APOE; the disease is stroke disorder.