Core-needle biopsy pathology reveals infiltrating micropapillary carcinoma, with tumor invasion of the dermis, the tumor clearly originates from the breast.<h4>Interventions</h4>The first-line treatment for advanced-stage breast cancer is the combination of cyclin-dependent kinase 4/6 inhibitors (CDK4/6 inhibitors) and aromatase inhibitors (AIs), specifically Abemaciclib and Anastrozole.<h4>Outcomes</h4>The patient has been treated for 44 months, and the disease has significantly improved. The gene discussed is CDK4; the disease is breast cancer.