The patient has remained neurologically stable under radiographic surveillance without any intervention.<h4>Results</h4>Radiographic, histological, and molecular data are presented for both cases and compared against the only other reported GTF2I::BRAF CNS case, as well as canonical versions of pilocytic astrocytoma.<h4>Conclusion</h4>To our knowledge, this is only the second case series highlighting a unique GTF2I::BRAF fusion and the first to describe it in adults in a spinal location. The gene discussed is BRAF; the disease is pilocytic astrocytoma.