These findings were validated using human psoriatic tissue samples and an imiquimod-induced murine psoriasis model to construct a predictive model termed IMscore.<h4>Results</h4>Our analysis identified five pivotal immune-related differentially expressed genes (ImDEGs): CXCL8, CXCL9, CCL18, RGS1, and SAMSN1. Here, RGS1 is linked to psoriasis.