With strong evidence of colocalization and consistent support from SMR analysis, the gene-predicted MASP1 was correlated with decreased IPF risk (OR<sub>meta</sub> = 0.46, 95% CI<sub>meta</sub>: 0.22‒0.99, P<sub>meta</sub> = 0.0478, PPH4 = 0.92). The gene discussed is MASP1; the disease is idiopathic pulmonary fibrosis.