Conversely, the gene-predicted WFIKKN2 was associated with an increased risk of IPF (OR<sub>meta</sub> = 1.31, 95% CI<sub>meta</sub> 1.15-1.48, P<sub>meta</sub> = 2.48E-05, PPH4 = 0.50). The gene discussed is WFIKKN2; the disease is idiopathic pulmonary fibrosis.