Functional experiments involving Gbp2 knockdown and overexpression, followed by a rescue experiment where absent in melanoma 2 (Aim2) was overexpressed in Gbp2-knockdown cells, were performed to elucidate its role and underlying mechanisms in regulating pyroptosis.<h4>Results</h4>Bioinformatics analysis identified OAS1, OAS2, IRF7, GBP2, and GBP1 as hub genes. Here, GBP2 is linked to melanoma.