The objective of this review is to investigate databases, including Web of Science, PubMed/MEDLINE, and Scopus were searched from October 1, 1998, to January 16, 2025, using Boolean combinations of keywords such as "PCOS," "naturopathy," "complementary and alternative medicine," "chromotherapy," "metformin," "insulin sensitivity," "obesity," and "diabetes." Naturopathic interventions consistently demonstrated favorable effects on PCOS outcomes across reviewed studies. This evidence concerns the gene INS and obesity due to melanocortin 4 receptor deficiency.