TNF and polycystic ovary syndrome: Embelin and nobiletin reproduced key anti-inflammatory and signaling effects, and their co-application produced an enhanced combined effect at the tested concentrations.<h4>Conclusion</h4>These findings suggest that GSW mitigates PCOS-like granulosa cell dysfunction under metabolic stress by suppressing TNF-α-associated inflammatory signaling, thereby relieving inhibition of the PI3K/Akt pathway.