Liver histological inflammation and macrophages (MΦs), liver sample transcriptomes by RNAseq, and stool microbiota by 16S rRNA sequencing were then assessed in RAG1KO mice.<h4>Results</h4>Prob-SF-CD4<sup>+</sup> T cells reduced the incidence and severity of liver inflammation and F4/80<sup>+</sup>MΦ infiltration by SF-CD4<sup>+</sup> T-cell transfer. This evidence concerns the gene CD4 and inflammation.