Plasma levels of interleukin (IL)-1β, IL-6, IL-8, IL-10, IL-17A, and tumor necrosis factor-alpha (TNF-α) were determined by electrochemiluminescence.<h4>Results</h4>The detection rate of childhood trauma was significantly higher in the MDD group than in HCs (80.59% vs. 31.58%). This evidence concerns the gene TNF and major depressive disorder.