The upregulation of immunoglobulins and pathways involved in the immune response (e.g. IL6/JAK/STAT3 and TNF-α via NF-kB signaling, interferon gamma response) further suggested a potential sensitivity to immunotherapy.<h4>Discussion</h4>Our findings provided basic evidence for immunotherapy efficacy in intimal sarcomas and identified potential molecular targets. This evidence concerns the gene IL6 and intimal sarcoma.