Moreover, human vascular endothelial cells stimulated with LPS for 2 hours exhibited downregulated <i>MAVS</i> RNA editing, consistent with findings in sepsis patients, as well as reduced <i>ADAR</i> and <i>MAVS</i> expression, suggesting a potential role for ADAR-mediated RNA editing in regulating <i>MAVS</i> expression during inflammation. The gene discussed is MAVS; the disease is Sepsis.