Consistently, <i>ADAR</i> and <i>MAVS</i> expression showed a positive correlation in both brain regions (Spearman's ρ > 0.49, <i>P</i> < 1 × 10<sup>-7</sup>).<h4>Discussion</h4>Our results thus provide new insight into the importance of the clinical epitranscriptomic landscape in different brain regions during sepsis and warrant further investigation into therapeutic strategies to mitigate cognitive impairment in sepsis. Here, MAVS is linked to Cognitive impairment.