FNDC5 and type 2 diabetes mellitus: This study compared the effects of aerobic exercise, resistance exercise, and their combination on skeletal muscle protein content and irisin-associated anabolic signaling in a rat model of T2DM.<h4>Methods</h4>Male rats with diet- and streptozotocin-induced T2DM were assigned to aerobic exercise, resistance exercise, combined aerobic-resistance exercise, or sedentary diabetic control for 8 weeks.