Using spatial proteomics of lung adenocarcinoma and adjacent tissue, we found that CD4<sup>+</sup> AICL<sup>+</sup> and CD8<sup>+</sup> KLRF1<sup>+</sup> T cells are enriched and spatially interacting in non-tumor regions, whereas both populations are reduced within tumor tissue. This evidence concerns the gene CD4 and lung adenocarcinoma.