TNF and psoriasis: Tumor necrosis factor (TNF)-related weak inducer of apoptosis (TWEAK) is a pro-inflammatory cytokine implicated in immune regulation and tissue remodeling, but its role in psoriatic disease remains incompletely understood.<h4>Methods</h4>This prospective case-control study included 100 subjects: 30 psoriasis patients receiving adalimumab, 30 PsA patients receiving methotrexate, and 40 healthy controls.