Upper respiratory tract infections are the main predisposing factor in children with GPP, and the MDA5 protein encoded by the IFIH1, functions as a key receptor for sensing upper respiratory tract viruses and may contribute to the induction of antiviral and immunological responses.<h4>Methods</h4>We performed whole-exome sequencing in 80 pediatric GPP patients and conducted rare variant association analyses against healthy controls. The gene discussed is IFIH1; the disease is Recurrent upper respiratory tract infections.